High Quality Content by WIKIPEDIA articles! The 1906 Florida Keys hurricane was a powerful and deadly hurricane that caused major impacts in Cuba and southern Florida. The fifth hurricane and third major hurricane of the season, the storm formed from a system near Barbados on October 4. By October 8, it had intensified into a tropical storm, and made landfall as a hurricane in Central America. The hurricane traveled towards Cuba, making landfall and wreaking havoc on the island. The storm then made a third landfall in the Florida Keys during the evening of October 18. At least 240 people were killed as a result of the hurricane, and damages totaled at least $4,135,000.