The 2005 Calder Cup Playoffs of the American Hockey League began on April 19, 2005. The sixteen teams that qualified, eight from each conference, played best-of-7 series for division semifinals, finals and conference finals. The conference champions played a best-of-7 series for the Calder Cup. The Calder Cup Final ended on June 10, 2005 with the Philadelphia Phantoms defeating the Chicago Wolves four games to none to win the second Calder Cup in team history. Philadelphia's Antero Nittymaki won the Jack A. Butterfield Trophy as playoff MVP.

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