The 2006 MasterCard Memorial Cup was held in Moncton, New Brunswick from May 19-28. The host team Moncton Wildcats were the only team guaranteed a spot in the tournament. The other teams were the champions of the Ontario Hockey League, the Peterborough Petes; the Western Hockey League champion Vancouver Giants; and the Quebec Major Junior Hockey League's Quebec Remparts, who were runners-up in the QMJHL final to the champion Wildcats. The Remparts won the Memorial Cup, defeating the Wildcats 6-2 in the first all-QMJHL final in tournament history. It also marked the first time in Memorial Cup history that the winning team was neither the host nor a league champion.

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