The 2006 UST Growling Tigers men's basketball team represented the University of Santo Tomas in the men's basketball tournament of the 69th season of the University Athletic Association of the Philippines. The Tigers defeated the Blue Eagles of the Ateneo de Manila University to win their nineteenth UAAP men's title, and their first since the 1996 season. Jervy Cruz was selected on the Mythical Five, and Jojo Duncil was named as the Most Valuable Player of the Finals.

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