High Quality Content by WIKIPEDIA articles! 3-Deoxyglucosone (3DG) is a dicarbonyl sugar that is synthesized through the Maillard reaction, and is detoxified to 3-deoxyfructose and 2-keto-3-deoxygluconic acid. 3DG is a precursor for the formation of advanced glycation end-products (AGEs): 3DG rapidly reacts with protein amino groups to form AGEs such as imidazolone, pyrraline, N6-(carboxymethyl)lysine and pentosidine. 3DG as well as AGEs play a role in the modification and cross-linking of long-lived proteins such as crystallin and collagen, contributing to diseases such as the vascular complications of diabetes, atherosclerosis, hypertension, Alzheimer’s disease inflammation and aging.