The total synthesis of Leucascandrolide A has been of interest to many chemists for the twelve years that have passed since it was first isolated. Leucascandrolide A's potent biological activity towards both yeast and cancer cell lines no doubt make it an interesting synthetic target, but synthetic chemists are most attracted by its distinct structural features including a 14-membered macrolide ring, two tri-substituted tetrahydropyran moieties, and eight stereocenters. Although the bulk of this book is dedicated to the methodology of the Mukaiyama aldol-Prins reaction and its application towards this total synthesis, there is a short chapter included at the end which details studies conducted towards a reagent-controlled, diastereoselective synthesis of 2,5-disubstituted tetrahydropyran rings.

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