High Quality Content by WIKIPEDIA articles! In immunology, affinity maturation is the process by which B cells produce antibodies with increased affinity for antigen during the course of an immune response. With repeated exposures to the same antigen, a host will produce antibodies of successively greater affinities. A secondary response can elicit antibodies with several logfold greater affinity than in a primary response. The main principles of the in vivo affinity maturation namely mutation and selection are utilised for the biotechnological approach of the in vitro affinity maturation.

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