High Quality Content by WIKIPEDIA articles! Agelasines are 7,9-dialkylpurinium salts isolated from marine sponges. They are considered secondary metabolites. Their contribution to the sponge is assumed to be some sort of protection against microorganisms. At the present time a total of eleven 9-methyladeninium salts, agelasine A-I, epiagelasine C and agelin B, are known [1-7]. All compounds carry a diterpenoid side chain in the adenine 7-position. The agelasines are closely related in structure with the agelasimines. Chemists have reproduced (-)-agelasine A [8], (-)-agelasine B [9], (-)-agelasine E [10], (-)-agelasine F [11] and (+)-agelasine D [12] by organic synthesis. Agelasines are associated with bioactivities such as antimicrobial and cytotoxic effects, as well as contractive responses of smooth muscles and inhibition of Na/K-ATPase. Furthermore, in vitro activity against Mycobacterium tuberculosis is reported for agelasine F [13].

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