High Quality Content by WIKIPEDIA articles! The Ais, or Ays were a tribe of Native Americans who inhabited the Atlantic Coast of Florida. They ranged from present day Cape Canaveral to the St. Lucie Inlet, in the present day counties of Brevard, Indian River, St. Lucie and northernmost Martin. They lived in villages and towns along the shores of the great lagoon called Rio de Ais by the Spanish, and now called the Indian River. The name Ais is derived from a great Indian Cacique (Chief).