High Quality Content by WIKIPEDIA articles! Alka-Seltzer is an effervescent antacid and pain reliever first marketed by the Dr. Miles Medicine Company. It was developed by Treneer in Elkhart Indiana. Alka-Seltzer is marketed for relief of minor aches, pains, inflammation, fever, headache, heartburn, sour stomach, indigestion, and hangovers, while neutralizing excess stomach acid. It was launched in 1931.