High Quality Content by WIKIPEDIA articles! Andrews is a city in and the county seat of Andrews County in the U.S. state of Texas within the West Texas region. The population was 10,448 in 2009. Along with Midland and Odessa, these cities form the Midland-Odessa Combined Statistical Area with a population of 241,316 in four counties. Andrews was the fastest growing Texas micropolitan in 2008 and 2009.