High Quality Content by WIKIPEDIA articles! The Anglo–Spanish War was a conflict between the English Protectorate of Oliver Cromwell and Spain, between 1654 and 1660. It was caused by commercial rivalry. Each side attacked the other`s commercial and colonial interests in various ways such as privateering and naval expeditions. In 1655, an English amphibious expedition invaded Spanish territory in the West Indies. The major land actions took place in the Spanish Netherlands. In 1657, England formed an alliance with France, merging the Anglo–Spanish war with the larger Franco–Spanish War.