High Quality Content by WIKIPEDIA articles! Anodyne is the fourth and final studio album by alternative country band Uncle Tupelo, released on October 5, 1993. The recording of the album was preceded by the departure of the original drummer Mike Heidorn and the addition of three new band members: bassist John Stirratt, drummer Ken Coomer, and multi-instrumentalist Max Johnston. The band signed with Sire Records shortly before recording the album; Anodyne was Uncle Tupelo`s only major label release until 89/93: An Anthology in 2002.