High Quality Content by WIKIPEDIA articles! Arachidonate 5-lipoxygenase also known as 5-lipoxygenase or 5-LO is an enzyme that in humans is encoded by the ALOX5 gene. Arachidonate 5-lipoxygenase is a member of the lipoxygenase family of enzymes. It transforms EFAs into leukotrienes and is a current target for pharmaceutical intervention in a number of diseases.