High Quality Content by WIKIPEDIA articles! The Autoimmune Regulator, abbreviated AIRE, is a human transcription factor expressed in the medulla of the thymus and is important in the prevention of autoimmune disease. In the thymus it causes transcription of a wide selection of organ-specific genes which create proteins that are usually only expressed in peripheral tissues, creating an "immunological self-shadow" in the thymus. It is important that self-reactive T cells which bind strongly to self-antigen are eliminated in the thymus (via the process of negative selection), otherwise they can later bind to their corresponding self-proteins and create an autoimmune reaction. So the expression of non-local proteins by AIRE reduces the threat of autoimmunity occurring later on by allowing for the elimination of auto-reactive T cells which bind antigens not traditionally found in the thymus.

Данное издание не является оригинальным. Книга печатается по технологии принт-он-деманд после получения заказа.