High Quality Content by WIKIPEDIA articles! Avenue C is a street in the Alphabet City neighborhood in the New York City borough of Manhattan. The street is also known as Loisaida Avenue, and it bears that official designation. It is located between Avenue B and Avenue D. It starts at East Houston Street and ends at 23rd Street, running nearly underneath the FDR Drive from 18th Street. Avenue C is still a transitional area, but rents are rising quickly and many long-time residents and businesses are being priced out of the market. This is typical of many parts of Manhattan since 1990.