High Quality Content by WIKIPEDIA articles! Banti`s syndrome (also known as Banti`s disease) is a chronic congestive enlargement of the spleen resulting in premature destruction of the red blood cells by the spleen. However, the term Banti`s syndrome is a term that was used in the past (but isn`t any longer) to describe patients with splenomegaly, hypersplenism and portal hypertension without cirrhosis and without occlusion of the portal venous system.