High Quality Content by WIKIPEDIA articles! ?2 microglobulin also known as B2M is a component of MHC class I molecules, which are present on all nucleated cells (so not red blood cells). In humans, the ?2 microglobulin protein is encoded by the B2M gene. ?2 microglobulin lies lateral to the ?3 chain on the cell surface. Unlike ?3, ?2 has no transmembrane region. Directly above ?2 (i.e. away from the cell) lies the ?1 chain, which itself is lateral to the ?2.

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