High Quality Content by WIKIPEDIA articles! Beta-thalassemia (?-thalassemia) is a form of thalassemia due to mutations in the HBB gene on chromosome 11, inherited in an autosomal recessive fashion. The severity of the disease depends on the nature of the mutation. * Alleles without a mutation that reduces function are characterized as (?). * Mutations are characterized as (?o) if they prevent any formation of ? chains. * Mutations are characterized as (?+) if they allow some ? chain formation to occur. (Note that the "+" in ?+ is relative to ?o, not ?.) In either case there is a relative excess of ? chains, but these do not form tetramers: rather, they bind to the red blood cell membranes, producing membrane damage, and at high concentrations they form toxic aggregates.

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