High Quality Content by WIKIPEDIA articles! BLOSUM (BLOcks of Amino Acid SUbstitution Matrix) is a substitution matrix used for sequence alignment of proteins. BLOSUM are used to score alignments between evolutionarily divergent protein sequences. BLOSUM is based on local alignments. BLOSUM was first introduced in a paper by Henikoff and Henikoff. They scanned the BLOCKS database for very conserved regions of protein families (that do not have gaps in the sequence alignment) and then counted the relative frequencies of amino acids and their substitution probabilities. Then, they calculated a log-odds score for each of the 210 possible substitutions of the 20 standard amino acids. All BLOSUM are based on observed alignments; they are not extrapolated from comparisons of closely related proteins like the PAM Matrices.

Данное издание не является оригинальным. Книга печатается по технологии принт-он-деманд после получения заказа.