High Quality Content by WIKIPEDIA articles! High Quality Content by WIKIPEDIA articles! Cat allergy in humans is an allergic reaction to one or more of the five known allergens produced by cats. The most common of these are the glycoprotein Fel d 1, secreted by the cat's sebaceous glands and Fel d 4, which is expressed in saliva. An allergic reaction is a histamine reaction that is usually characterized by coughing, wheezing, chest tightening, itching, nasal congestion, rash, watering eyes, sneezing and similar symptoms. Fel d 4 is the product of the cat major urinary protein gene. It is primarily expressed in the submandibular salivary gland and is deposited onto dander as the cat grooms itself. A study found that 63% of cat allergic people have antibodies against the protein, and most had higher titres than of anti-Fel d 1 IgE.

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