High Quality Content by WIKIPEDIA articles! Centerville is a city in and the county seat of Appanoose County, Iowa, United States. The population was 5,528 in the 2010 census, a decline from 5,924 in the 2000 census. After the turn of the 20th century Centerville had a booming coal mining industry that attracted many European immigrants. The city today remains the home of many Swedish-Americans, Italian-Americans, Croatian-Americans, Albanian-Americans and others descended from immigrants who worked in the mines.