High Quality Content by WIKIPEDIA articles! Cerebellar abiotrophy (CA), also referred to as the cerebellar cortical abiotrophy (CCA), which is a genetic neurological disease in animals best known to affect certain breeds of horses and dogs. It develops when the neurons known as Purkinje cells, located in the cerebellum of the brain, begin to die off. These cells affect balance and coordination. They have a critical role to play in the brain. The Purkinje layer allows communication between the granular and molecular cortical layers in the cerebellum. Put simply, without Purkinje cells, an animal loses its sense of space and distance, making balance and coordination difficult.