High Quality Content by WIKIPEDIA articles! In thermodynamics, chemical potential, also known as partial molar free energy, is a form of potential energy that can be absorbed or released during a chemical reaction. It may also change during a phase transition. The chemical potential of a species in the mixture can be defined as the slope of the free energy of the system with respect to a change in the number of moles of just that species. Thus, it is the partial derivative of the free energy with respect to the amount of the species, all other species` concentrations in the mixture remaining constant, and at constant temperature. When pressure is constant, chemical potential is the partial molar Gibbs free energy. At chemical equilibrium or in phase equilibrium the total sum of chemical potentials is zero, as the free energy is at a minimum.