This book is compilation of my graduate research work done at New York University with Professor Tamar Schlick. Specifically, work described in this book explores at an atomically detailed level large-scale conformational transitions involved in the nucleotide insertion pathways of high and low fidelity DNA polymerases. Insights into dynamics of polymerases provides a link between available static structural information and macroscopic kinetic data and help understand fidelity mechanisms. In general scientists who wish to apply modeling and simulation to investigate dynamics of complex biomolecules may benefit from the description of interesting problems and computational approaches covered in the book.

Данное издание не является оригинальным. Книга печатается по технологии принт-он-деманд после получения заказа.