Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Deamidation is a chemical reaction in which an amide functional group is removed from an organic compound. In biochemistry, the reaction is important in the degradation of proteins because it damages the amide-containing side chains of the amino acids asparagine and glutamine. In the biochemical deamidation reaction, the side chain of an asparagine attacks the following peptide group, forming a symmetric succinimide intermediate. The symmetry of the intermediate results in two products of its hydrolysis, either aspartate or in isoaspartate, which is a beta amino acid. This process is considered a deamidation because the amide in the asparagine side chain is replaced by a carboxylate group. However, a similar reaction can occur in aspartate side chains, yielding a partial conversion to isoaspartate

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