High Quality Content by WIKIPEDIA articles! Diane Chambers is a fictional character, portrayed by Shelley Long, of the American television show Cheers. Diane appeared as a main character of Cheers until the Season Five finale, "I Do, Adieu" (1987). She appeared as a guest character in the series finale, "One for the Road" (1993), and in four episodes of Cheers spin-off, Frasier. Notoriously, she has on-off relationships with the lothario bartender Sam Malone (Ted Danson) and a one-year relationship with Frasier Crane (Kelsey Grammer).