High Quality Content by WIKIPEDIA articles! Diffusion MRI is a magnetic resonance imaging (MRI) method that produces in vivo images of biological tissues weighted with the local microstructural characteristics of water diffusion, which is capable of showing connections between brain regions. The field of diffusion MRI can be understood in terms of two distinct classes of application—diffusion weighted MRI and diffusion tensor MRI. Diffusion MRI is a key technology in the creation of the human connectome, which is the structure and organization of the connections throughout the central nervous system.