High Quality Content by WIKIPEDIA articles! Electrochemotherapy is a therapeutic approach providing delivery into cell interior of non-permeant drugs with intracellular targets. It is based on the local application of short and intense electric pulses that transiently permeabilize cell membrane, thus allowing transport of molecules otherwise not permitted by a cellular membrane . Applications for treatment of cutaneous and subcutaneous tumors have reached clinical use (antitumor electrochemotherapy using bleomycin or cisplatin) . Electrochemotherapy with bleomycin has been used to treat the patient for the first time in 1991 at the Institute Gustave Roussy in France , while electrochemotherapy with cisplatin has been used to treat the patient for the first time in 1995 at the Institute of Oncology, Ljubljana, Slovenia . Since then more than 4000 patients were treated with electrochemotherapy all over the world (Australia, Austria, Belgium, Bulgaria, Denmark, France, Germany, Greece, Hungary, Ireland, Italy, Japan, Mexico, Nicaragua, Poland, Portugal, Slovenia, Spain, Sweden, UK, USA). Recently, new electrochemotherapy modalities have been developed for treatment of internal tumors using surgical procedures, endoscopic routes or percutaneous approaches to gain access to the treatment area .