High Quality Content by WIKIPEDIA articles! Evansville is the third-largest city in the U.S. state of Indiana and the largest city in Southern Indiana. As of the 2010 census, the city had a total population of 117,429. It is the county seat of Vanderburgh County and the regional hub for both Southwestern Indiana and the Illinois-Indiana-Kentucky Tri-State Area. In 2008 a population estimate put the Evansville Metropolitan Statistical Area at 350,261.