Rheumatoid arthritis (RA) represents a chronic inflammatory autoimmune rheumatic disease characterized by articular and extra-articular, systemic involvement, resulting in important disability and severe impairment of quality of life. Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation of the joint. Although the precise pathogenesis of RA remains unclear, T cells and B cells are central to the mechanisms of joint inflammation and disease progression. The role of B cells in RA pathology has been highlighted by the clinical improvements in RA patients receiving B-cell depleting therapies such as rituximab, an anti-CD20 antibody, and the increased interest in the role of auto antibodies in RA.

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