High Quality Content by WIKIPEDIA articles! Glucosepane is a lysine-arginine protein cross-linking product and advanced glycation end product (AGE) derived from D-glucose. It is an irreversible, covalent cross-link product that has been found to make intermolecular and intramolecular cross-links in the collagen of the extracellular matrix (ECM) and crystallin of the eyes. Covalent protein cross-links irreversibly link proteins together in the ECM of tissues. Glucosepane is currently considered to be the most important cross-linking AGE yet discovered because its levels are found to be 10 to 1000 times higher in human tissue than any other cross-linking AGE.