High Quality Content by WIKIPEDIA articles! The Great Lakes Megalopolis consists of the group of North American metropolitan areas which surround the Great Lakes region mainly within the Midwestern United States, the Southern Ontario area of Canada, along with large parts of Pennsylvania, New York, and Quebec. The region extends from the Milwaukee–Chicago corridor to the Detroit–Toronto corridor, and includes Buffalo, Cincinnati, Cleveland, Columbus, Dayton, Erie, Fort Wayne, Grand Rapids, Indianapolis, Louisville, Ottawa, Quad Cities, Rochester, and Toledo, reaching as far as Pittsburgh and Kansas City. The region had an estimated population of 59,144,461 is projected to reach about 65 million by 2025. As of 2012, the largest city is Chicago while the fastest growing city is Toronto, which is also the regions second largest city.