High Quality Content by WIKIPEDIA articles! Humacao (Spanish pronunciation: ) is a city in Puerto Rico located in the eastern coast of the island, north of Yabucoa; south of Naguabo; east of Las Piedras; and west of Vieques Passage. Humacao is spread over 10 wards and Humacao Pueblo (The downtown area and the administrative center of the city). It is part of the San Juan-Caguas-Guaynabo Metropolitan Statistical Area.