Illegal drug trade in Colombia refers to the practice of producing and distributing illegal drugs with psychoactive effects in the Republic of Colombia. Colombia has had four major drug trafficking cartels which eventually created a new social class and influenced several aspects of Colombian culture. Coca, marijuana and other drugs had been part of the lifestyle of some indigenous, but the worldwide demand of psychoactive drugs during the 1960s and 1970s eventually increased the production and processing of these in Colombia. Prohibition laws were implemented in the United States and Colombia to quell the perceived negative effects of drugs in society and to punish those who either possessed, produced or commercially distributed illegal drugs for profit. Since the establishment of the War on Drugs, the United States and European countries have provided financial, logistical and tactical aid to the government of Colombia in order to implement plans to combat the illegal drug trade. The most notable of these programs has been the Plan Colombia which also intended to combat terrorist organizations producing illegal drugs in Colombia.

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