High Quality Content by WIKIPEDIA articles! The Illinois Central Railroad (reporting mark IC), sometimes called the Main Line of Mid-America, is a railroad in the central United States, with its primary routes connecting Chicago, Illinois with New Orleans, Louisiana and Birmingham, Alabama. A line also connected Chicago with Sioux City, Iowa (1870). There was a significant branch to Omaha, Nebraska (1899) west of Fort Dodge, Iowa and another branch reaching Sioux Falls, South Dakota (1877) starting from Cherokee, Iowa.