High Quality Content by WIKIPEDIA articles! The interaction information (McGill 1954) or co-information (Bell 2003) is one of several generalizations of the mutual information, and expresses the amount information (redundancy or synergy) bound up in a set of variables, beyond that which is present in any subset of those variables. Unlike the mutual information, the interaction information can be either positive or negative. This confusing property has likely retarded its wider adoption as an information measure in machine learning and cognitive science.