High Quality Content by WIKIPEDIA articles! Interstate 22 (I-22), when it is completed, is an Interstate highway that will follow the U.S. Route 78 (US 78) corridor on a 213-mile-long (343 km) route from Memphis, Tennessee, to Birmingham, Alabama. I-22 will connect I-240 and I-40 and I-55 (indirectly) in the northwest with I-65 and (indirectly) I-20/I-59 in the southeast. Hence, I-22 will help form a freeway to connect downtown Atlanta with Birmingham, Memphis, Little Rock, and Oklahoma City.