High Quality Content by WIKIPEDIA articles! Interstate 74 (I-74) is an Interstate Highway in the Midwestern and Southeastern United States. Its western end is at an intersection with Interstate 80 in Davenport, Iowa; the eastern end of its Midwest segment is at an intersection with Interstate 75 in Cincinnati, Ohio. It also exists as several other disconnected sections of highways in North Carolina (see details); also see List of gaps in Interstate Highways.