High Quality Content by WIKIPEDIA articles! Interstate 75 (I-75) is a major north–south Interstate Highway in the Great Lakes and Southeastern regions of the United States. It travels from State Road 826 (Palmetto Expressway) and State Road 924 (Gratigny Parkway) in Hialeah, Florida (northwest of Miami) to Sault Ste. Marie, Michigan, at the Ontario, Canada, border. Interstate 75 passes through six different states: Florida, Georgia, Tennessee, Kentucky, Ohio and Michigan.