High Quality Content by WIKIPEDIA articles! Interstate 75 (I-75) is a part of the Interstate Highway System and runs from Hialeah, Florida, a few miles northwest of Miami to Sault Ste. Marie in the Upper Peninsula of Michigan. I-75 begins its national northward journey in Hialeah, running along the western parts of South Florida before traveling westward across Alligator Alley, resuming its northward direction in Naples, running along Florida`s Gulf Coast, passing the cities of Ft. Myers, Port Charlotte, and the Tampa Bay Area, before turning inward towards Ocala, Gainsville and Lake City before leaving the state and entering Georgia.