High Quality Content by WIKIPEDIA articles! Isogenic human disease models are a family of cells that are selected or engineered to accurately model the genetics of a specific patient population, in vitro ("within glass"; or, commonly, "in the lab", in an artificial environment). They are provided with a genetically matched ‘normal cell’ to provide an isogenic system to research disease biology and novel therapeutic agents. They can be used to model any disease with a genetic foundation. Cancer is one such disease for which isogenic human disease models have been widely used.