High Quality Content by WIKIPEDIA articles! James Evan Wilson,M.D., is a fictional character on the Fox medical drama House. He is played by Robert Sean Leonard. The character first appears in the show`s pilot episode when he introduces a medical case to Dr. Gregory House, the protagonist of the show. Wilson is Dr. House`s only true friend, and frequently provides him with consultations and aid. Wilson is the head of the Department of Oncology at Princeton-Plainsboro Teaching Hospital.