High Quality Content by WIKIPEDIA articles! The method kinITC for kinetic Isothermal Titration Calorimetry is an extension of the classical ITC technique in view of obtaining kinetic information in addition to thermodynamic information. It has been described in full in, and in a simplified and less general form in. In short, kinITC allows obtaining with a single technique both the information obtained with classical ITC and with a technique like Surface Plasmon Resonance (SPR). In situations where a chemical reaction proceeds clearly through two successive kinetic steps, the major interest of kinITC is of being potentially more informative alone than ITC and SPR used jointly, but in a classical way. The experimental limitation for its successful application comes from the response time of the instrument, which prevents from obtaining kinetic information if the reaction proceeds too rapidly. It turns out that this is not so much a severe limitation for many reactions occurring with biological macromolecules. The kinITC method is thus quite appropriate in biology. Note that, as pionereed long time ago by J. Sturtevant, ITC has already been used for deriving kinetic information in biochemistry, but only in the particular situations of enzyme kinetics.