High Quality Content by WIKIPEDIA articles! Anne-Marie, Lady Byrne is a fictional character in the BBC medical drama Holby City, portrayed by actress Jane Asher. The character first appeared on 10 May 2007 in episode "After the Fall" - series 9, episode 30 of the programme. After several guest appearances as the mother of established character Joseph Byrne throughout series 9 and 10, Asher signed a three-month contract to become a series regular from May 2008 onwards, for a period of 10 episodes. Her initial storyline saw her son`s girlfriend, Jac Naylor, embark on an affair with Anne-Marie`s husband and Joseph`s father, Lord Charles Byrne - eventually culminating in his death, and leaving the character a widow. Upon her return to the programme, she takes over Lord Charles` position as Executive Chairman of the Byrne Foundation - a charity committed to research into Cardiac Valve Disease.