High Quality Content by WIKIPEDIA articles! The latency-associated nuclear antigen or LANA-1, is a Kaposi`s sarcoma-associated herpesvirus (KSHV) latent protein which has been suspected of playing a crucial role in modulating viral and cellular gene expression.. LANA was found by Moore and colleagues as a speckled nuclear antigen present in primary effusion lymphoma cells that reacts with antibodies from patients with KS. It is commonly used as an antigen in blood tests to detect antibodies in persons that have been exposed to KSHV.