High Quality Content by WIKIPEDIA articles! Mister Ed is an American television situation comedy produced by Filmways that first aired in syndication from January 5 to July 2, 1961 and then on CBS from October 1, 1961 to February 6, 1966. A total of 143 episodes were produced, 26 for syndication, and 117 for CBS. It was the first TV show to premiere as a mid-season replacement.