High Quality Content by WIKIPEDIA articles! Three Rivers is a medical drama which premiered on CBS on October 4, 2009 and ended on July 3, 2010. The series is set in Pittsburgh, Pennsylvania at a fictional hospital specializing in transplants, with Alex O`Loughlin starring as a famous transplant surgeon. Other cast members include Katherine Moennig, Daniel Henney, Christopher Hanke, Alfre Woodard, and Justina Machado. Julia Ormond portrayed Dr. Sophia Jordan in the pilot.