High Quality Content by WIKIPEDIA articles! Locked-in syndrome is a condition in which a patient is aware and awake but cannot move or communicate due to complete paralysis of nearly all voluntary muscles in the body except for the eyes. Total locked-in syndrome is a version of locked-in syndrome where the eyes are paralyzed as well. It is the result of a brain stem lesion in which the ventral (anterior) part of the pons is damaged. The term for this disorder was coined by Fred Plum and Posner in 1966. In French, the common term is maladie de l'emmure vivant, literally translated as "walled-in-alive disease"; in German, it is sometimes called Eingeschlossensein. Locked-in syndrome is also known as cerebromedullospinal disconnection, de-efferented state, pseudocoma, and ventral pontine syndrome.

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