High Quality Content by WIKIPEDIA articles! Maryland Route 222 (MD 222) is a state highway in the U.S. state of Maryland. The state highway runs 11.36 miles (18.28 km) from MD 7 in Perryville north to U.S. Route 1 (US 1) near Conowingo. MD 222 parallels the Susquehanna River in western Cecil County, connecting Perryville and Conowingo with Port Deposit. Due to limitations in the highway in Port Deposit, including a steep hill and a low railroad bridge, the state highway has a truck bypass that uses MD 275, MD 276, and US 1 through Woodlawn and Rising Sun to connect Interstate 95 (I-95) with US 222 in Conowingo.